Fragmentation of Rapid Eye Movement and Nonrapid Eye Movement Sleep without Total Sleep Loss Impairs Hippocampus-Dependent Fear Memory Consolidation

Pregabalin enhances nonrapid eye movement sleep.

Pregabalin, an analog of gamma-aminobutyric acid (GABA) that does not interact with GABA receptors, is in development as an analgesic, an anticonvulsant, and an anxiolytic. We evaluated the potential somnogenic actions of pregabalin in rats and compared it to those of triazolam, a widely used hypnotic. Pregabalin increased the duration of nonrapid eye movement sleep (NREMS) and decreased rapid ...

Rapid Eye Movement Sleep

• Rapid eye movement (REM) sleep was first identified by its most obvious feature: rapid eye movements occurring during sleep. In most adult mammals the electroencephalogram (EEG) of the neocortex is low in voltage during REM sleep. The hippocampus exhibits regular high-voltage theta waves throughout REM sleep. • The key brain structure for generating REM sleep is the brainstem, particularly th...

Rapid eye movement sleep: asleep-dependent process.

1. K. S. Lashley, Brain Mechanisms and Intelligence (Dover, New York, 1963). 2. L. Petrinovich and D. Bliss, J. Comp. Physiol. Psychol. 61, 136 (1966); J. W. Stewart and H. W. Ades, ibid. 44, 479 (1951). 3. R. J. Douglas, Psychol. Bull. 67, 416 (1967); G. Goddard, ibid. 62, 89 (1964); J. M. Warren and K. Akert, The Frontal Granular Cortex and Behavior (McGraw-Hill, New York, 1964). 4. Analyses ...

Complementary roles of slow-wave sleep and rapid eye movement sleep in emotional memory consolidation.

Although rapid eye movement sleep (REM) is regularly implicated in emotional memory consolidation, the role of slow-wave sleep (SWS) in this process is largely uncharacterized. In the present study, we investigated the relative impacts of nocturnal SWS and REM upon the consolidation of emotional memories using functional magnetic resonance imaging (fMRI) and polysomnography (PSG). Participants ...

Title : Complementary roles of slow - wave sleep and rapid eye movement sleep in emotional memory consolidation